Description

(2R,3R)-3-(2,4-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-Yl)Thiobutyramide is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of advanced active pharmaceutical ingredients (APIs), particularly in the antifungal and agrochemical sectors. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of triazole-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of advanced triazole antifungal APIs.
• Agrochemical Research: Used in the development of novel fungicides and plant protection agents.
• Process Chemistry: Serves as a key starting material or intermediate in route scouting and scale-up for new chemical entities.
• Asymmetric Synthesis: Utilized in studies and production requiring specific (2R,3R) stereochemistry.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Custom Synthesis: A building block for the contract manufacturing of specialized fine chemicals and proprietary compounds.

Basic Information

Product Name	(2R,3R)-3-(2,4-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-Yl)Thiobutyramide
CAS No.	170863-34-0
Molecular Formula	C14H15F2N3O2S
Molecular Weight	327.35 g/mol
Synonyms	(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide; (2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide; 170863-34-0; (2R,3R)-Isomer of a triazole thiobutyramide derivative; Difluorophenyl triazole thiobutyramide intermediate
EINECS	Contact for details

Quality Control

Our (2R,3R)-3-(2,4-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-Yl)Thiobutyramide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged exposure to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2R,3R)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.