Description

5'-Guanylic Acid, 2'-Deoxy-2'-Fluoro- is a chemically modified nucleotide analog, a key building block in the synthesis of oligonucleotides. This compound matters for its role in creating stable, nuclease-resistant RNA and DNA strands, which are essential for advanced therapeutic and diagnostic applications. It is primarily needed by pharmaceutical R&D teams and manufacturers in the fields of antisense oligonucleotide (ASO) therapeutics, siRNA development, and molecular diagnostics.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite monomer for constructing therapeutic oligonucleotides that modulate gene expression.
• siRNA and miRNA Research: Used to introduce stability against enzymatic degradation in RNA interference constructs.
• Diagnostic Probe Development: Serves as a modified base in probes for FISH (Fluorescence In Situ Hybridization) and PCR assays to enhance specificity and stability.
• Apiamer Construction: A component in the synthesis of nuclease-resistant aptamers for therapeutic and sensing applications.
• Structural Biology Studies: Employed to investigate RNA structure, function, and protein-nucleic acid interactions.
• Pre-clinical Pharmaceutical Development: A key raw material in the research and development stages of novel nucleic acid-based drugs.

Basic Information

Product Name	5'-Guanylic Acid, 2'-Deoxy-2'-Fluoro-
CAS No.	170784-58-4
Molecular Formula	C10H13FN5O7P
Molecular Weight	365.21 g/mol
Synonyms	2'-Deoxy-2'-fluoro-Guanosine 5'-monophosphate; 2'-F-dGMP; 2'-Fluoro-2'-deoxyguanosine 5'-monophosphate; 2'-F-dGuo-5'-MP; 9-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]amino]phosphonic acid; 2'-Fluoro-2'-deoxyguanosine 5'-(dihydrogen phosphate); 2'-F-GMP; dG(2'F)MP
EINECS	Contact for details

Quality Control

Our production of 5'-Guanylic Acid, 2'-Deoxy-2'-Fluoro- adheres to stringent quality protocols suitable for pharmaceutical research. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from advanced analytical techniques including HPLC, NMR, and MS. We support compliance with relevant guidelines for advanced therapeutic medicinal product (ATMP) starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.