Description

2'-Deoxyuridine 5'-[Hydrogen [[Hydroxy(Phosphonooxy)Phosphinyl]Methyl]Phosphonate] is a chemically modified nucleoside analog, specifically a deoxyuridine derivative with a complex bisphosphonate chain. This compound is of significant interest in advanced pharmaceutical research and development, particularly in the design of novel antiviral and anticancer agents. It serves as a critical building block or prodrug intermediate for scientists in medicinal chemistry and biochemistry. Target users include R&D laboratories, pharmaceutical manufacturers, and academic institutions focused on nucleotide-based therapeutics.

Application

• Medicinal Chemistry Research: As a key intermediate in the synthesis of novel nucleotide analogs for antiviral (e.g., anti-herpesvirus, anti-hepatitis) and anticancer drug discovery programs.
• Biochemical Probes: Used to study enzyme mechanisms, particularly those involving thymidylate synthase or other nucleotide-processing enzymes, due to its modified phosphate backbone.
• Prodrug Development: Serves as a precursor for bisphosphonate prodrugs designed for targeted delivery and improved bioavailability of active nucleotide metabolites.
• Antisense/Oligonucleotide Synthesis: Potential use as a modified monomer in the creation of nuclease-resistant oligonucleotides for therapeutic and diagnostic applications.
• Radiopharmaceuticals: The bisphosphonate moiety allows for potential chelation of radionuclides, enabling its use in developing targeted imaging or therapeutic agents.
• Enzyme Inhibition Studies: Acts as a substrate analog to investigate and inhibit specific kinases or polymerases involved in DNA synthesis and repair pathways.

Basic Information

Product Name	2'-Deoxyuridine 5'-[Hydrogen [[Hydroxy(Phosphonooxy)Phosphinyl]Methyl]Phosphonate]
CAS No.	170428-84-9
Molecular Formula	C10H17N2O13P3
Molecular Weight	466.16 g/mol
Synonyms	dUMP-α,β-Methylene Diphosphonate; 2'-Deoxyuridine 5'-(α,β-Methylenediphosphonate); Deoxyuridine Methylene Diphosphonate; dUMP-CH2-PP; 5'-O-[[(Hydroxyphosphinyl)methyl]phosphono]-2'-deoxyuridine; P1-(2'-Deoxyuridin-5'-yl) P3-hydroxy P2-methylenetriphosphonate; UDP-CH2-PP (context-specific); Deoxyuridine Bisphosphonate Analog
EINECS	Contact for details

Quality Control

Our 2'-Deoxyuridine 5'-[Hydrogen [[Hydroxy(Phosphonooxy)Phosphinyl]Methyl]Phosphonate] is produced under strict quality management systems suitable for research and development. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity by HPLC, NMR confirmation, and other critical parameters are provided with every shipment. We can support development projects requiring material aligned with ICH guidelines for impurity profiling and stability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.