Description

Enzastaurin (Ly317615) is a potent and selective small-molecule inhibitor of protein kinase C beta (PKCβ), which plays a critical role in cell signaling pathways related to proliferation and survival. This compound is of significant interest for its potential in oncology research, particularly in targeting cancers with dysregulated PKC signaling. It serves as a valuable reference standard and active pharmaceutical ingredient (API) for researchers and developers in the pharmaceutical and biotechnology sectors, focusing on novel therapeutic discovery and development.

Application

• Oncology Research: Primary use as a biochemical tool for studying PKCβ-mediated signaling pathways in various cancer cell lines and models.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical R&D and manufacturing.
• Drug Discovery & Development: Used as a key intermediate or active pharmaceutical ingredient (API) in preclinical studies for novel anti-cancer therapeutics.
• Mechanistic Studies: Employed to investigate the role of PKCβ in angiogenesis, apoptosis, and tumor cell proliferation.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro kinase inhibition assays to identify and validate new drug candidates.

Basic Information

Product Name	Enzastaurin (Ly317615)
CAS No.	170364-57-5
Molecular Formula	C32H29N5O2
Molecular Weight	515.61 g/mol
Synonyms	Ly317615; Enzastaurin Hydrochloride (salt form); 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione; PKCβ Inhibitor
EINECS	Contact for details

Quality Control

Our Enzastaurin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the material should be handled in a low-humidity environment and the container kept tightly sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.