Description

2'-Azido-N4-Benzoyl-2',3'-Dideoxy-5'-o-Dmt-Cytidine is a sophisticated, protected nucleoside derivative designed for advanced oligonucleotide synthesis. This compound matters as a critical building block for the development of modified antisense oligonucleotides and other therapeutic nucleic acids, enabling precise control over genetic material. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and specialized CROs/CMOs engaged in the discovery and manufacturing of next-generation genetic medicines and molecular biology research tools.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite precursor for introducing modified cytidine analogs into therapeutic oligonucleotide sequences.
• siRNA and miRNA Research: Used in the solid-phase synthesis of RNAi agents to study gene silencing and develop RNA-based therapeutics.
• Prodrug Development: Serves as an intermediate in the creation of nucleoside prodrugs for antiviral and anticancer applications.
• Chemical Biology Probes: Enables the synthesis of labeled or tagged nucleosides for studying nucleic acid interactions and enzyme mechanisms.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry and biochemistry for exploring novel nucleic acid architectures.
• GMP Manufacturing: Sourced as a high-purity starting material for cGMP production of active pharmaceutical ingredients (APIs) in oligonucleotide drugs.

Basic Information

Product Name	2'-Azido-N4-Benzoyl-2',3'-Dideoxy-5'-o-Dmt-Cytidine
CAS No.	170236-33-6
Molecular Formula	C37H36N6O6
Molecular Weight	660.73 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-azido-2',3'-dideoxy-N4-benzoylcytidine; 2'-Azido-5'-O-DMT-N4-benzoyl-2',3'-ddC; 2'-N3-5'-DMT-N4-Bz-2',3'-ddC; DMT-Azido-ddC(Bz); 2'-Azido-2',3'-dideoxy-5'-O-(4,4'-dimethoxytrityl)-N4-benzoylcytidine; Protected 2'-Azido-2',3'-dideoxycytidine; Cytidine, 2'-azido-2',3'-dideoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N4-benzoyl-
EINECS	Contact for details

Quality Control

Every batch of 2'-Azido-N4-Benzoyl-2',3'-Dideoxy-5'-o-Dmt-Cytidine is manufactured and tested under strict quality systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), and impurity profiles are available for all shipments. Our quality commitment supports compliance with relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.