Description

(2S-Cis)-2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolane-4-Methanol, Methanesulfonate (Ester)Ketoconazole is a high-purity synthetic intermediate and a key derivative of the broad-spectrum antifungal agent ketoconazole. This compound is of significant commercial value for the development and production of advanced pharmaceutical formulations targeting fungal infections. It is primarily required by manufacturers in the pharmaceutical and fine chemical sectors for research, process development, and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of ketoconazole and related antifungal APIs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of finished dosage forms for systemic and topical antifungal treatments.
• Research & Development: Serves as a reference standard and a precursor in medicinal chemistry for developing new azole-based antifungal agents.
• Veterinary Medicine: Employed in the formulation of antifungal treatments for animals.
• Biochemical Research: Used in studies investigating the mechanism of action of imidazole antifungals and sterol biosynthesis inhibition.

Basic Information

Product Name	(2S-Cis)-2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolane-4-Methanol, Methanesulfonate (Ester)Ketoconazole
CAS No.	170210-50-1
Molecular Formula	C26H27Cl2N3O6S
Molecular Weight	580.48 g/mol
Synonyms	Ketoconazole Methanesulfonate; Ketoconazole Mesylate; cis-1-Acetyl-4-[4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine methanesulfonate; (2S,4R)-Ketoconazole Methanesulfonate; Nizoral Impurity (Mesylate); Ketoconazole Methanesulfonate Salt; Ketoconazole derivative (mesylate ester).
EINECS	Contact for details

Quality Control

Our (2S-Cis)-2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolane-4-Methanol, Methanesulfonate (Ester)Ketoconazole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.