Description

Nepicastat CAS NO 170151-25-4 is a potent and selective inhibitor of dopamine β-hydroxylase (DBH), an enzyme crucial in catecholamine biosynthesis. This pharmacological profile makes it a valuable research compound for investigating cardiovascular and neurological disorders related to sympathetic nervous system overactivity. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) focused on hypertension, heart failure, and substance abuse.

Application

• Pharmaceutical Research & Development: A key reference standard and active compound in preclinical studies targeting dopamine β-hydroxylase inhibition.
• Cardiovascular Disease Research: Investigation of novel therapeutic pathways for hypertension, congestive heart failure, and other conditions influenced by norepinephrine levels.
• Neuropharmacology Studies: Exploration of its effects on the central nervous system, including potential applications in addiction research and stress-related disorders.
• Biochemical Assay Development: Used as a control inhibitor in enzymatic assays to study DBH activity and screen for new inhibitor candidates.
• Academic & Clinical Research: Serves as a critical tool for understanding catecholamine metabolism and its role in various physiological and pathological states.

Basic Information

Item	Detail
Product Name	Nepicastat
CAS No.	170151-25-4
Molecular Formula	C₁₇H₂₀N₄O₂
Molecular Weight	312.37 g/mol
Synonyms	Nepicastat; RS-25560-197; (R)-2-Hydroxy-N-(1-methyl-2-phenylethyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (R)-2-Hydroxy-N-(1-methyl-2-phenylethyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide; Dopamine β-Hydroxylase Inhibitor; DBH Inhibitor
EINECS	Contact for details

Quality Control

Our Nepicastat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.