Description

Exatecan Mesylate is a potent, water-soluble derivative of the topoisomerase I inhibitor camptothecin, designed to enhance stability and therapeutic efficacy. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of novel anticancer therapeutics, particularly for solid tumors. It is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and companies specializing in oncology drug development and production.

Application

• Oncology Drug Development: Primary use as a key active pharmaceutical ingredient (API) in the formulation of injectable anticancer drugs.
• Pharmaceutical Intermediates: Serves as a crucial synthetic intermediate for the production of more complex camptothecin analogs and antibody-drug conjugates (ADCs).
• Clinical Research Materials: Supplied as a reference standard or bulk material for preclinical studies and clinical trials investigating topoisomerase I inhibition.
• Biochemical Research: Used in vitro to study mechanisms of DNA damage, cell cycle arrest, and apoptosis in cancer cell lines.
• Anticancer Agent Synthesis: A building block for medicinal chemists synthesizing new derivatives with improved pharmacokinetic profiles.

Basic Information

Product Name	Exatecan Mesylate
CAS No.	169869-90-3
Molecular Formula	C₂₄H₂₇N₃O₈S
Molecular Weight	517.55 g/mol
Synonyms	Exatecan methanesulfonate; DX-8951f; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonate; DX 8951 f; DX-8951; BAY 59-8862; Camptothecin derivative DX-8951
EINECS	Contact for details

Quality Control

Our Exatecan Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and MS, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.