Description

2-Thio-2'-Deoxycytidine is a modified nucleoside analog of deoxycytidine, where the oxygen atom at the 2-position of the cytosine base is replaced by a sulfur atom. This structural modification is of significant interest in the development of novel therapeutic agents and biochemical research tools, particularly in the fields of antiviral and anticancer drug discovery. It serves as a critical building block and research chemical for pharmaceutical R&D, biotechnology, and academic laboratories focused on nucleic acid chemistry and molecular biology.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving DNA polymerases, nucleoside kinases, and other nucleic acid-metabolizing enzymes.
• Antisense Oligonucleotide Development: Incorporated into oligonucleotide sequences to study structure-activity relationships and enhance nuclease resistance.
• Proteomics & Genomics: Serves as a specialized reagent in the study of DNA damage, repair mechanisms, and epigenetic modifications.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2-Thio-2'-Deoxycytidine
CAS No.	169557-13-5
Molecular Formula	C9H13N3O4S
Molecular Weight	259.28 g/mol
Synonyms	2-Thio-2'-deoxycytidine; 2-Thiodeoxycytidine; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,2-dihydropyrimidine-2-thione; 2'-Deoxy-2-thiocytidine; dC(S); 2-Thio-dC; 2-S-2'-Deoxycytidine
EINECS	Contact for details

Quality Control

Our 2-Thio-2'-Deoxycytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.