Description

(4R,5R)-5-(2,4-Difluorophenyl)-4-Methyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-2-Oxazolidinone is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound serves as a critical chiral building block in the synthesis of novel antifungal agents and other bioactive molecules. It is essential for R&D laboratories and production facilities in the pharmaceutical and fine chemical industries seeking to develop or manufacture next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of potent antifungal drugs, particularly triazole-based compounds.
• Antifungal Agent Development: Core scaffold for developing new candidates targeting fungal ergosterol biosynthesis.
• Organic Synthesis Research: Valuable building block for medicinal chemists exploring structure-activity relationships (SAR) in oxazolidinone and triazole chemistry.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes for the cost-effective and scalable production of active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	(4R,5R)-5-(2,4-Difluorophenyl)-4-Methyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-2-Oxazolidinone
CAS No.	169058-26-8
Molecular Formula	C14H13F2N3O2
Molecular Weight	293.27 g/mol
Synonyms	(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-oxazolidin-2-one; (4R-cis)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone; 2-Oxazolidinone, 5-(2,4-difluorophenyl)-4-methyl-5-[(1H-1,2,4-triazol-1-yl)methyl]-, (4R,5R)-; Fluconazole Intermediate; Difluorophenyl Oxazolidinone Derivative
EINECS	Contact for details

Quality Control

Our (4R,5R)-5-(2,4-Difluorophenyl)-4-Methyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure compliance with stringent specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.