Description

2-Amino-5-Chloro-α-(2-Cyclopropylethynyl)-α-(Trifluoromethyl)Benzenemethanol is a sophisticated chiral benzenemethanol derivative, distinguished by its trifluoromethyl and cyclopropylethynyl functional groups. This compound serves as a critical advanced pharmaceutical intermediate (API) for the synthesis of novel therapeutic agents, where its unique structure imparts specific biological activity and metabolic stability. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, antiviral agents, or other specialized therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities, leveraging the trifluoromethyl group for enhanced lipophilicity and bioavailability.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for clinical trial material and commercial drug production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for methodological studies in asymmetric synthesis and organofluorine chemistry.

Basic Information

Product Name	2-Amino-5-Chloro-α-(2-Cyclopropylethynyl)-α-(Trifluoromethyl)Benzenemethanol
CAS No.	168834-43-3
Molecular Formula	C13H11ClF3NO
Molecular Weight	289.68 g/mol
Synonyms	2-Amino-5-chloro-α-(2-cyclopropylethynyl)-α-(trifluoromethyl)benzenemethanol; Benzenemethanol, 2-amino-5-chloro-α-[2-(cyclopropylethynyl)]-α-(trifluoromethyl)-; α-(2-Cyclopropylethynyl)-α-(trifluoromethyl)-2-amino-5-chlorobenzyl alcohol; (R/S)-2-Amino-5-chloro-α-(2-cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol; 168834-43-3; Advanced Pharmaceutical Intermediate CAS 168834-43-3
EINECS	Contact for details

Quality Control

Our production of 2-Amino-5-Chloro-α-(2-Cyclopropylethynyl)-α-(Trifluoromethyl)Benzenemethanol adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.