Description

2'-O-MOE-Adenosine is a chemically modified nucleoside analog, specifically an adenosine derivative with a 2'-O-methoxyethyl (MOE) substitution on the ribose sugar. This modification is critical for enhancing the stability, binding affinity, and nuclease resistance of oligonucleotides, making it a foundational building block for advanced therapeutic and research applications. It is an essential raw material for pharmaceutical companies, biotechnology research institutes, and diagnostic developers engaged in the synthesis of antisense oligonucleotides (ASOs), siRNA, and other novel nucleic acid-based modalities.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of therapeutic ASOs targeting genetic diseases, cancers, and metabolic disorders.
• siRNA and miRNA Therapeutics: Used in the manufacture of small interfering RNA (siRNA) and microRNA (miRNA) constructs to achieve potent and specific gene silencing.
• Research & Diagnostic Probes: Serves as a modified nucleotide in the development of high-affinity, nuclease-resistant hybridization probes for molecular diagnostics and basic research.
• Pharmaceutical Intermediate: An advanced intermediate in the production of active pharmaceutical ingredients (APIs) for novel nucleic acid drugs.
• Bioconjugation and Labeling: The reactive sites allow for further functionalization with reporter molecules (e.g., fluorophores, biotin) for tracking and detection studies.

Basic Information

Product Name	2'-O-MOE-Adenosine
CAS No.	168427-74-5
Molecular Formula	C13H19N5O6
Molecular Weight	341.32 g/mol
Synonyms	2'-O-(2-Methoxyethyl)adenosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-[[(2-methoxyethoxy)methyl]oxymethyl]oxolan-2-yl]-6-aminopurine; 2'-MOE-A; 2'-O-Methoxyethyladenosine; Adenosine, 2'-O-(2-methoxyethyl)-; 2'-O-(2-Methoxyethyl)-adenosine; MOE-Adenosine
EINECS	Contact for details

Quality Control

Our 2'-O-MOE-Adenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for critical pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We support compliance with cGMP, ICH Q7 guidelines, and relevant regulatory frameworks (e.g., FDA, EMA) for advanced therapeutic intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) for long-term storage to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.