Description

n-(4-Benzyloxy-Phenyl)-2,2,2-Trifluoro-Acetimidoyl Chloride is a specialized trifluoroacetimidoyl chloride derivative, a key synthetic intermediate in modern organic chemistry. Its primary value lies in its role as a versatile electrophilic reagent for introducing the trifluoroacetimidate group, enabling the synthesis of complex molecules with enhanced properties. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl moiety enhances biological activity.
• Material Science Research: Serves as a building block for creating novel polymers, liquid crystals, and advanced materials with specific optical or electronic properties.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions for constructing complex biaryl and heteroaryl structures.
• Peptidomimetics & Prodrug Development: Employed in medicinal chemistry for the design and synthesis of peptidomimetics and prodrug candidates.
• Chemical Biology Probes: Utilized in the synthesis of chemical probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	n-(4-Benzyloxy-Phenyl)-2,2,2-Trifluoro-Acetimidoyl Chloride
CAS No.	168267-73-0
Molecular Formula	C15H11ClF3NO
Molecular Weight	313.70 g/mol
Synonyms	N-(4-(Benzyloxy)phenyl)-2,2,2-trifluoroethanimidoyl chloride; 2,2,2-Trifluoro-N-[4-(phenylmethoxy)phenyl]ethanimidoyl chloride; 4-Benzyloxy-α,α,α-trifluoroacetimidoyl chloride; N-(4-Benzyloxyphenyl)-2,2,2-trifluoroacetimidoyl chloride; 168267-73-0; (4-Benzyloxyphenyl)(trifluoroacetyl)imino chloride
EINECS	Contact for details

Quality Control

Our n-(4-Benzyloxy-Phenyl)-2,2,2-Trifluoro-Acetimidoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.