Description

1-Piperidinecarbonyl Chloride, 2-Methyl-, (R)- (9Ci) is a high-purity, chiral building block of significant value in advanced organic synthesis. Its primary importance lies in its role as a reactive intermediate for introducing the (R)-2-methylpiperidine moiety, a key structural motif in pharmaceutical development. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced, optically active pesticides and herbicides where specific stereochemistry is required for efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for the synthesis of chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetic Research: Employed in medicinal chemistry for constructing peptide analogs and peptidomimetics with enhanced metabolic stability and bioavailability.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in chiral chemistry.
• Academic and R&D Laboratories: Used in research institutions for methodological development in organic synthesis and exploring new chemical entities.

Basic Information

Product Name	1-Piperidinecarbonyl Chloride, 2-Methyl-, (R)- (9Ci)
CAS No.	168253-03-0
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	(R)-2-Methylpiperidine-1-carbonyl chloride; (R)-1-(Chlorocarbonyl)-2-methylpiperidine; (R)-2-Methyl-1-piperidinecarbonyl chloride; (R)-N-Carboxy-2-methylpiperidine chloride; 2-Methylpiperidine-1-carbonyl chloride, (R)-; (R)-α-Methylpipecolyl chloride; (R)-2-Methylpipecolyl chloride
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarbonyl Chloride, 2-Methyl-, (R)- (9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is subjected to comprehensive analytical testing, including chiral HPLC, to confirm identity, purity, and optical rotation. Certificates of Analysis (COA) detailing all test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.