Description

1-Piperidinecarbonyl Chloride, 2-Methyl-, (S)- (9Ci) is a high-value, chiral building block and reagent used in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of enantiomerically pure pharmaceuticals and agrochemicals, where stereochemical control is critical. It is primarily needed by research and development chemists and process development teams in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the research and production of enantiomerically pure herbicides, fungicides, and pesticides for enhanced efficacy and environmental safety.
• Peptidomimetic Chemistry: Serves as a building block for creating peptide analogs and protease inhibitors by introducing the (S)-2-methylpiperidine moiety.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Academic and Industrial R&D: A valuable reagent for method development and exploring new synthetic routes in medicinal and process chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom projects requiring high-purity chiral intermediates.

Basic Information

Product Name	1-Piperidinecarbonyl Chloride, 2-Methyl-, (S)- (9Ci)
CAS No.	168253-02-9
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	(S)-2-Methylpiperidine-1-carbonyl chloride; (S)-1-(Chlorocarbonyl)-2-methylpiperidine; (S)-N-Carboxy-2-methylpiperidine chloride; (S)-2-Methyl-1-piperidinecarbonyl chloride; (S)-2-Methylpiperidine-1-carboxylic acid chloride; 2-Methylpiperidine-1-carbonyl chloride, (S)-; (S)-α-Methylpipecolyl chloride
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarbonyl Chloride, 2-Methyl-, (S)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and highly volatile. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to minimize evaporation. Store away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.