Description

1-Pyrrolidinecarbonyl Chloride, 2,5-Dimethyl-, (2R,5R)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant value in advanced organic synthesis. Its core utility lies in its role as a reactive acyl chloride derivative, enabling the efficient introduction of the 2,5-dimethylpyrrolidine moiety into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients where stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the specific stereochemistry can influence efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Peptidomimetic Research: Employed in medicinal chemistry to construct peptidomimetic scaffolds that mimic the structure and function of natural peptides.
• Custom Chemical Synthesis: A versatile building block for contract research and manufacturing organizations (CROs/CMOs) working on custom synthesis projects for clients.
• Material Science: Potential applications in the synthesis of specialized polymers or functional materials with tailored properties.

Basic Information

Product Name	1-Pyrrolidinecarbonyl Chloride, 2,5-Dimethyl-, (2R,5R)- (9Ci)
CAS No.	168253-01-8
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	(2R,5R)-2,5-Dimethylpyrrolidine-1-carbonyl chloride; (2R,5R)-2,5-Dimethyl-1-pyrrolidinecarbonyl chloride; (R,R)-2,5-Dimethylpyrrolidine-1-carbonyl chloride; trans-2,5-Dimethylpyrrolidine-1-carbonyl chloride; 1-Carbonyl chloride-2,5-dimethylpyrrolidine, (2R,5R)-; Chiral 2,5-dimethylpyrrolidine acyl chloride
EINECS	Contact for details

Quality Control

Our production of 1-Pyrrolidinecarbonyl Chloride, 2,5-Dimethyl-, (2R,5R)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and undergoes rigorous analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended long-term storage temperature is 2-8°C. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.