Description

1H-Indole-2-Carbonyl Chloride, 5-Fluoro-1-Methyl- (9Ci) is a high-purity, reactive chemical building block essential for advanced organic synthesis. Its core value lies in its role as a key acylating agent for introducing the 5-fluoro-1-methylindole-2-carbonyl moiety, a privileged scaffold in medicinal chemistry. This compound is critically needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor for synthesizing novel drug candidates, particularly in oncology and CNS (Central Nervous System) therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, leveraging the biological activity of the fluorinated indole structure.
• Chemical Biology Probe Synthesis: Employed to create labeled or tagged molecules for studying biological pathways and protein interactions.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Academic & Contract Research: A vital reagent for synthetic methodology development and the exploration of new chemical spaces in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1H-Indole-2-Carbonyl Chloride, 5-Fluoro-1-Methyl- (9Ci)
CAS No.	168201-49-8
Molecular Formula	C10H7ClFNO
Molecular Weight	211.62 g/mol
Synonyms	5-Fluoro-1-methyl-1H-indole-2-carbonyl chloride; 5-Fluoro-1-methylindole-2-carbonyl chloride; 1-Methyl-5-fluoroindole-2-carbonyl chloride; 1-Methyl-5-fluoro-1H-indole-2-carbonyl chloride; 2-Carbonyl chloride-5-fluoro-1-methylindole; (5-Fluoro-1-methyl-1H-indol-2-yl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Indole-2-Carbonyl Chloride, 5-Fluoro-1-Methyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.