Description

1H-Pyrazole-5-Carbonyl Chloride, 1-Methyl-3-(1-Methylethyl)- (9Ci) is a specialized heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of a substituted pyrazole carbonyl moiety, which is essential for constructing molecules with targeted biological activity. This high-purity intermediate is primarily needed by pharmaceutical R&D and agrochemical manufacturers for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the pyrazole core contributes to binding efficacy.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers and advanced organic materials with specific electronic or photophysical properties.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses serving the life sciences industry, facilitating scale-up from milligram to kilogram quantities.

Basic Information

Product Name	1H-Pyrazole-5-Carbonyl Chloride, 1-Methyl-3-(1-Methylethyl)- (9Ci)
CAS No.	167889-80-7
Molecular Formula	C8H11ClN2O
Molecular Weight	186.64 g/mol
Synonyms	1-Isopropyl-3-methyl-1H-pyrazole-5-carbonyl chloride; 3-Isopropyl-1-methyl-1H-pyrazole-5-carbonyl chloride; 1-Methyl-3-(1-methylethyl)-1H-pyrazole-5-carbonyl chloride; 5-Carbonyl chloride-1-methyl-3-isopropylpyrazole; Isopropylmethylpyrazole carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrazole-5-Carbonyl Chloride, 1-Methyl-3-(1-Methylethyl)- (9Ci) adheres to a stringent quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.