Description

(2R)-1-{4-[(1Ar,6R,10Bs)-1,1-Difluoro-1,1A,6,10B-Tetrahydrodibenzo[A,E]Cyclopropa[C]Cyclohepten-6-Yl]Piperazin-1-Yl}-3-(Quinolin-5-Yloxy)Propan-2-Ol is a sophisticated chiral organic compound featuring a complex polycyclic framework integrated with a piperazine and quinoline pharmacophore. This molecule is of significant interest for its potential as a high-value pharmaceutical intermediate or active pharmaceutical ingredient (API) in advanced therapeutic research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel small-molecule drugs, particularly in areas requiring structurally unique scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, or inflammatory diseases.
• Active Pharmaceutical Ingredient (API) Research: Used directly in preclinical and clinical research to investigate its pharmacological activity, metabolism, and toxicity profile.
• Medicinal Chemistry & Drug Discovery: Provides a structurally complex core for structure-activity relationship (SAR) studies and lead optimization programs in academic and industrial R&D labs.
• Biochemical Research: Employed as a tool compound or probe to study specific enzyme interactions or receptor binding mechanisms in biological systems.
• Reference Standard: Supplied as a high-purity analytical standard for quality control, method development, and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	(2R)-1-{4-[(1Ar,6R,10Bs)-1,1-Difluoro-1,1A,6,10B-Tetrahydrodibenzo[A,E]Cyclopropa[C]Cyclohepten-6-Yl]Piperazin-1-Yl}-3-(Quinolin-5-Yloxy)Propan-2-Ol
CAS No.	167354-41-8
Molecular Formula	C31H29F2N3O2
Molecular Weight	513.58 g/mol
Synonyms	1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cycloheptene-6-piperazinepropanol derivative; (2R)-1-[4-[(1aR,6R,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-1-piperazinyl]-3-(5-quinolinyloxy)-2-propanol; CAS 167354-41-8; UNII-9F8S6A1D1C; 9F8S6A1D1C; (R)-1-(4-((1aR,6R,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is subjected to comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support development and commercial projects requiring compliance with ICH guidelines and can tailor specifications to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.