Description

Omapatrilat is a potent, dual-acting vasopeptidase inhibitor that targets both angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). This unique mechanism of action makes it a compound of significant interest for cardiovascular research and therapeutic development. It is primarily utilized by pharmaceutical R&D organizations and academic institutions focused on hypertension, heart failure, and renal disease pathways.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the development of novel cardiovascular therapeutics.
• Biochemical Studies: For investigating the renin-angiotensin-aldosterone system (RAAS) and natriuretic peptide system in preclinical models.
• Mechanism of Action (MoA) Research: Used to study the dual inhibition of ACE and NEP and its effects on blood pressure and vascular function.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Academic Research: Employed in university and institutional labs for cardiovascular pharmacology and physiology studies.

Basic Information

Product Name	Omapatrilat
CAS No.	167305-00-2
Molecular Formula	C19H26N2O4
Molecular Weight	346.42 g/mol
Synonyms	BMS-186716; (4S,7S,10aS)-5-Oxo-4-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,3,4,7,8,10a-hexahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid; BMS 186716; Vanlev (brand name, discontinued); Dual vasopeptidase inhibitor
EINECS	Contact for details

Quality Control

Our Omapatrilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm
Assay	95.0% - 105.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.