Description

2-[2-(2-Azidoethoxy)Ethoxy]Ethanamine is a specialized bifunctional organic compound featuring both an azide and a primary amine group, connected by a flexible polyether spacer. This unique structure makes it a highly valuable click chemistry reagent and a versatile heterobifunctional crosslinker for bioconjugation and polymer modification. It is essential for researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors who require precise and efficient methods for coupling biomolecules or functionalizing surfaces.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a heterobifunctional linker to covalently attach cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides via orthogonal click chemistry and amine-reactive chemistries.
• Polymer Functionalization and Surface Modification: Enables the introduction of azide or amine functionalities onto polymer backbones, nanoparticles, or solid surfaces for creating smart materials, hydrogels, or biosensor platforms.
• Click Chemistry Synthesis: Serves as a key building block in Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions to construct complex molecular architectures.
• Proteomics and Biomarker Discovery: Facilitates the labeling, enrichment, and isolation of biomolecules for mass spectrometry analysis and activity-based protein profiling (ABPP).
• Diagnostic Reagent Manufacturing: Employed in the synthesis of reagents for immunoassays, lateral flow tests, and other diagnostic tools requiring stable covalent linkages.
• Materials Science Research: Used to develop novel crosslinked networks, self-healing materials, and stimuli-responsive polymers with tailored properties.

Basic Information

Product Name	2-[2-(2-Azidoethoxy)Ethoxy]Ethanamine
CAS No.	166388-57-4
Molecular Formula	C6H14N4O2
Molecular Weight	174.20 g/mol
Synonyms	2,2'-(Ethylenedioxy)di(ethyl azide) amine; Azido-PEG3-amine; 11-Azido-3,6,9-trioxaundecan-1-amine; N3-PEG3-NH2; 2-[2-(2-Azidoethoxy)ethoxy]ethanamine; 3,6,9-Trioxa-11-azidoundecylamine; Amino-PEG3-azide; 1-Amino-11-azido-3,6,9-trioxaundecane
EINECS	Contact for details

Quality Control

Every batch of 2-[2-(2-Azidoethoxy)Ethoxy]Ethanamine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive research and production applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. Due to its highly volatile and easily oxidized nature, prolonged exposure to air, moisture, or elevated temperatures should be avoided. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.