Description

Benzenebutanoyl Chloride, 2-Fluoro- is a specialized fluorinated aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the reactive acid chloride group enables efficient amide or ester bond formation, and the fluorine substituent offers unique electronic and steric properties to modulate the bioactivity and physicochemical characteristics of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for constructing novel active ingredients and fine chemical intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, including potential kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used to incorporate fluorinated phenyl moieties into novel herbicides, fungicides, and plant growth regulators to enhance efficacy and environmental stability.
• Material Science: Building block for creating specialized monomers and polymers with tailored properties, such as fluorinated polyamides or polyesters for high-performance coatings and resins.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing complex fluorinated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine-18 Radiochemistry: Potential precursor for developing novel positron emission tomography (PET) tracers, leveraging the fluorine atom for radiolabeling strategies.
• Fine Chemical Production: Employed in the custom synthesis of complex fluorinated fragrances, dyes, and liquid crystals.

Basic Information

Product Name	Benzenebutanoyl Chloride, 2-Fluoro-
CAS No.	166251-26-9
Molecular Formula	C₁₀H₁₀ClFO
Molecular Weight	200.64 g/mol
Synonyms	2-Fluorobenzenebutanoyl Chloride; 4-(2-Fluorophenyl)butanoyl Chloride; 2-Fluoro-γ-phenylbutyryl Chloride; 4-(2-Fluorophenyl)butyryl Chloride; 2-Fluorohydrocinnamoyl Chloride, Propyl Homolog; γ-(2-Fluorophenyl)butyryl Chloride; Butanoyl chloride, 4-(2-fluorophenyl)-
EINECS	Contact for details

Quality Control

Every batch of Benzenebutanoyl Chloride, 2-Fluoro- is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our commitment to quality assurance supports compliance with the stringent requirements of cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.