Description

Acetoxy-Tms-Ethynylbenzen is a specialized organosilicon building block featuring both acetoxy and trimethylsilyl-protected ethynyl functional groups. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions and the synthesis of novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring alkyne or silicon-containing motifs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides, herbicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for the development of advanced polymers, dendrimers, and silicon-based functional materials.
• Cross-Coupling Reactions: An effective substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Organic Synthesis Reagent: Employed in academic and industrial R&D labs for the modular construction of complex organic molecules and natural product analogs.
• Ligand and Catalyst Development: Used in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	Acetoxy-Tms-Ethynylbenzen
CAS No.	165825-13-8
Molecular Formula	C13H16O2Si
Molecular Weight	232.35 g/mol
Synonyms	1-(Acetoxy)-4-[(trimethylsilyl)ethynyl]benzene; 4-(Trimethylsilylethynyl)phenyl acetate; p-(Trimethylsilylethynyl)phenyl acetate; Acetoxy(4-((trimethylsilyl)ethynyl))benzene; TMS-Ethynylphenyl Acetate; 4-Acetoxyphenyl(trimethylsilyl)acetylene; [4-(Trimethylsilylethynyl)phenoxy]ethanone
EINECS	Contact for details

Quality Control

Our Acetoxy-Tms-Ethynylbenzen is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.