Description

Thymidine, 2',3'-Didehydro-3'-Deoxy-, Compd. With 1-Methyl-2-Pyrrolidinone (1:1) (9Ci) CAS NO 165172-60-1 is a high-purity nucleoside derivative complexed with 1-methyl-2-pyrrolidinone (NMP) to enhance its stability and solubility. This compound is a critical intermediate in the synthesis of modified nucleosides and nucleotides, which are essential building blocks for antiviral and anticancer research. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing novel therapeutic agents and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA synthesis and repair mechanisms.
• Antiviral Drug Development: Serves as a building block for potential active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Probe Synthesis: Utilized in the creation of labeled nucleosides for molecular biology and diagnostic applications.
• Organic Synthesis: Valuable chiral synthon for constructing complex molecules in medicinal chemistry programs.
• Academic Research: Fundamental material for studying the structure-activity relationships of modified nucleosides.

Basic Information

Product Name	Thymidine, 2',3'-Didehydro-3'-Deoxy-, Compd. With 1-Methyl-2-Pyrrolidinone (1:1) (9Ci)
CAS No.	165172-60-1
Molecular Formula	C10H12N2O5 • C5H9NO
Molecular Weight	383.38 g/mol
Synonyms	2',3'-Didehydro-3'-deoxythymidine NMP complex; d4T NMP complex; Stavudine related compound NMP complex; 1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine compound with 1-methylpyrrolidin-2-one (1:1); Thymidine, 2',3'-didehydro-3'-deoxy-, compd. with 1-methyl-2-pyrrolidinone; NSC 684192 (NMP complex); Anti-HIV nucleoside intermediate NMP adduct.
EINECS	Contact for details

Quality Control

Our Thymidine, 2',3'-Didehydro-3'-Deoxy-, Compd. With 1-Methyl-2-Pyrrolidinone (1:1) (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
1-Methyl-2-pyrrolidinone Content (HPLC)	0.9 - 1.1 molar equivalent

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.