Description

1-(((2R,4R)-4-((Benzyloxy)Methyl)-2-(2,4-Difluorophenyl)Tetrahydrofuran-2-Yl)Methyl)-1H-1,2,4-Triazole is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the antifungal and antiviral therapeutic classes. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and large-scale API manufacturers seeking reliable, high-quality building blocks for complex synthetic routes.

Application

• Key Intermediate in Antifungal API Synthesis: Serves as a critical chiral precursor in the production of triazole-based antifungal agents.
• Pharmaceutical Process Development: Used in route scouting and optimization for new chemical entities (NCEs) targeting fungal and viral infections.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the commercial-scale synthesis of finished drug substances under cGMP conditions.
• Biochemical Research: Utilized as a reference standard or probe molecule in enzymatic and receptor-binding studies related to sterol biosynthesis inhibition.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring this specialized intermediate.

Basic Information

Product Name	1-(((2R,4R)-4-((Benzyloxy)Methyl)-2-(2,4-Difluorophenyl)Tetrahydrofuran-2-Yl)Methyl)-1H-1,2,4-Triazole
CAS No.	165115-83-3
Molecular Formula	C22H23F2N3O2
Molecular Weight	399.44 g/mol
Synonyms	(2R,4R)-4-[(Benzyloxy)methyl]-2-(2,4-difluorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran; 1-[(2R,4R)-4-(Benzyloxymethyl)-2-(2,4-difluorophenyl)tetrahydrofuran-2-yl]methyl-1H-1,2,4-triazole; Voriconazole Intermediate; UK-109496 Key Intermediate; Difluorophenyl Benzyloxymethyl Tetrahydrofuranyl Triazole; (2R,4R)-2-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-4-(benzyloxymethyl)tetrahydrofuran
EINECS	Contact for details

Quality Control

Our 1-(((2R,4R)-4-((Benzyloxy)Methyl)-2-(2,4-Difluorophenyl)Tetrahydrofuran-2-Yl)Methyl)-1H-1,2,4-Triazole is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere such as nitrogen after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,4R isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.