Description

(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-Methylenepiperidin-1-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound matters as a critical building block in the synthesis of novel antifungal agents, offering researchers and manufacturers a reliable starting point for complex molecular development. It is primarily needed by pharmaceutical R&D teams, process chemists, and manufacturers in the active pharmaceutical ingredient (API) sector focused on developing next-generation therapeutic solutions.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of triazole-based antifungal APIs.
• Antifungal Drug Development: Serves as a core structural component for novel compounds targeting fungal CYP51 enzymes.
• Organic Synthesis Research: Used in academic and industrial laboratories for studying structure-activity relationships (SAR) in medicinal chemistry.
• Process Chemistry & Scale-Up: Provides a defined, high-quality starting material for optimizing synthetic routes from lab to pilot and commercial scale.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Item	Detail
Product Name	(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-Methylenepiperidin-1-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol
CAS No.	164905-19-5
Molecular Formula	C18H22F2N4O
Molecular Weight	348.39 g/mol
Synonyms	(2R,3R)-Isavuconazole Intermediate; (2R,3R)-BAL4815 Intermediate; (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; (2R,3R)-Isavuconazonium Sulfate Precursor; (2R,3R)-BAL8557; (2R,3R)-Antifungal Intermediate; (2R,3R)-CYP51 Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-Methylenepiperidin-1-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,3R)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.