Description

S,S-Efinaconazole CAS NO 164650-45-7 is a potent and highly specific triazole antifungal agent. This compound is of significant commercial importance due to its targeted mechanism of action, which inhibits fungal ergosterol biosynthesis, offering high efficacy with a favorable safety profile. It is primarily required by the pharmaceutical industry for the formulation of topical antifungal treatments, specifically targeting onychomycosis and other dermatological fungal infections.

Application

• Active Pharmaceutical Ingredient (API) in topical antifungal solutions and creams for the treatment of onychomycosis (fungal nail infection).
• Key component in prescription dermatological formulations for tinea pedis (athlete's foot), tinea corporis (ringworm), and other superficial cutaneous mycoses.
• Used in veterinary pharmaceutical preparations for treating fungal skin infections in animals.
• Critical intermediate in advanced pharmaceutical research and development of new antifungal agents.
• Reference standard in analytical laboratories for quality control and method development of antifungal products.

Basic Information

Product Name	S,S-Efinaconazole
CAS No.	164650-45-7
Molecular Formula	C18H22F2N4O
Molecular Weight	348.39 g/mol
Synonyms	(2S,3S)-Efinaconazole; (2S,3S)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; Jublia (brand name active ingredient); KP-103; SS-717; (S,S)-Efinaconazole; Efinaconazole (S,S-isomer)
EINECS	Contact for details

Quality Control

Our S,S-Efinaconazole is manufactured under strict quality management systems to meet the rigorous standards of the pharmaceutical industry. Every batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure identity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) confirming compliance with in-house specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (S,S-Isomer)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.