Description

Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, (1R-Trans)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, incorporating a cyclopropane ring, a reactive acid chloride group, and a halogenated ethenyl moiety, making it a versatile precursor for constructing complex, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients where precise stereochemistry and functional group manipulation are critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical building block in the creation of advanced crop protection agents, including novel insecticides and herbicides, where its halogenated structure contributes to bioactivity.
• Advanced Material Precursor: Used in the synthesis of specialized polymers and liquid crystals, where the cyclopropane and halogenated vinyl groups can impart unique thermal and optical properties.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial-scale production of complex organic molecules requiring this specific stereochemical framework.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, (1R-Trans)- (9Ci)
CAS No.	163877-51-8
Molecular Formula	C10H11Cl2FO
Molecular Weight	237.10 g/mol
Synonyms	(1R,3R)-3-[(1Z)-2-Chloro-2-fluoroethenyl]-2,2-dimethylcyclopropanecarbonyl chloride; (1R-trans)-3-[(Z)-2-Chloro-2-fluoroethenyl]-2,2-dimethylcyclopropanecarboxylic acid chloride; trans-(1R,3R)-3-[(Z)-2-Chloro-2-fluoroethenyl]-2,2-dimethylcyclopropanecarbonyl chloride; 3-(2-Chloro-2-fluoroethenyl)-2,2-dimethylcyclopropanecarboxylic acid chloride, (1R,3R)-; Z-Isomer of the chiral cyclopropanecarbonyl chloride derivative.
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, (1R-Trans)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and moisture. Due to the acid chloride functionality and light-sensitive nature, handling under an inert atmosphere (e.g., nitrogen or argon) is recommended for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.