Description

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((2-(Methylthio)Ethyl)Amino)-2-((3,3,3-Trifluoropropyl)Thio)-9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diol is a high-purity, nucleoside analog derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate for synthesizing novel therapeutic agents, particularly in antiviral and anticancer drug discovery programs. It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of next-generation nucleotide-based therapies.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate purine metabolism and related pathways.
• Proteomics & Molecular Biology: Potential utility in the development of labeled probes or tools for studying nucleic acid interactions and cellular processes.
• Medicinal Chemistry: Core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of drug candidates.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology and drug discovery.

Basic Information

Product Name	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((2-(Methylthio)Ethyl)Amino)-2-((3,3,3-Trifluoropropyl)Thio)-9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diol
CAS No.	163706-58-9
Molecular Formula	C17H24F3N5O4S2
Molecular Weight	483.53 g/mol
Synonyms	2'-Deoxy-2'-(methylthio)ethylamino-2-(3,3,3-trifluoropropylthio)adenosine; 2'-Deoxy-2'-[(2-(methylthio)ethyl)amino]-2-[(3,3,3-trifluoropropyl)thio]adenosine; 9H-Purin-9-one, 2-[(3,3,3-trifluoropropyl)thio]-6-[[2-(methylthio)ethyl]amino]-; 2-(3,3,3-Trifluoropropylthio)-6-[(2-methylthioethyl)amino]purine riboside; Adenosine, 2'-deoxy-2'-[(2-(methylthio)ethyl)amino]-2-[(3,3,3-trifluoropropyl)thio]-; CAS 163706-58-9
EINECS	Contact for details

Quality Control

Our (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((2-(Methylthio)Ethyl)Amino)-2-((3,3,3-Trifluoropropyl)Thio)-9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diol is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can support development toward cGMP compliance for advanced project stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.