Description

Pseudouridine Cep is a high-purity, modified nucleoside building block essential for advanced biochemical research and therapeutic development. This compound is critical for the synthesis of stable mRNA and other nucleic acid analogs, offering enhanced resistance to degradation. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on next-generation therapeutics, including mRNA vaccines and oligonucleotide-based drugs.

Application

• mRNA Vaccine & Therapeutic Synthesis: As a key modified nucleoside for incorporating pseudouridine into mRNA sequences to improve stability and reduce immunogenicity.
• Oligonucleotide & Antisense Drug Development: Used in the solid-phase synthesis of research-grade and therapeutic oligonucleotides.
• Biochemical Research: Serves as a critical reagent in studies of RNA structure, function, and translation mechanisms.
• Diagnostic Probe Manufacturing: Employed in the production of labeled probes and primers for sensitive molecular diagnostics.
• Pharmaceutical Intermediates: Acts as a sophisticated building block for the synthesis of novel nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Pseudouridine Cep
CAS No.	163496-23-9
Molecular Formula	C14H19N3O9
Molecular Weight	373.32 g/mol
Synonyms	5-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-[(2R,3S,4R,5R)-5-(2-Cyanoethoxy(diisopropylamino)phosphanyl)-3,4-dihydroxyoxolan-2-yl]pyrimidine-2,4-dione; 1-(2-Cyanoethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N4-benzoyl-2'-O-methyl-pseudouridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; Pseudouridine Phosphoramidite; ψ-CEP; 5-ribosyluracil CEP; Pseudouridine 2'-O-methyl-CE Phosphoramidite
EINECS	Contact for details

Quality Control

Our Pseudouridine Cep is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure it meets the stringent requirements for nucleic acid synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below under an inert atmosphere (argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.