Description

5-(n-Methyl-n-Trifluoromethylacetyl)Aminomethyl Uridine is a high-purity, modified nucleoside building block of significant interest in advanced pharmaceutical and biochemical research. Its core value lies in the strategic incorporation of a trifluoromethyl group, which can dramatically alter the metabolic stability, lipophilicity, and binding characteristics of the resulting oligonucleotides or nucleoside analogs. This compound is essential for researchers and manufacturers in the fields of antisense therapy, diagnostic probe development, and medicinal chemistry, where precise molecular modifications are required to develop next-generation therapeutics and research tools.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite precursor for introducing modified uridine residues to enhance nuclease resistance and target affinity.
• siRNA and miRNA Research: Used in the solid-phase synthesis of chemically modified RNA strands to improve stability and pharmacokinetic profiles for gene silencing applications.
• Diagnostic Probe Development: Serves as a building block for fluorescent or radioactive probes used in molecular diagnostics and hybridization assays.
• Medicinal Chemistry & Drug Discovery: A key intermediate in the synthesis of novel nucleoside analog prodrugs targeting viral infections or oncology.
• Bioconjugation and Labeling: The reactive aminomethyl group allows for conjugation with various reporter molecules or delivery vehicles.
• Academic and Institutional Research: Used in fundamental studies exploring RNA structure, function, and protein-RNA interactions.

Basic Information

Product Name	5-(n-Methyl-n-Trifluoromethylacetyl)Aminomethyl Uridine
CAS No.	163496-07-9
Molecular Formula	C14H16F3N3O7
Molecular Weight	395.29 g/mol
Synonyms	5-[(Methyl(trifluoroacetyl)amino)methyl]uridine; 5-(N-Methyl-N-trifluoroacetamido)methyluridine; 5-(N-Methyl-N-trifluoroacetyl)aminomethyluridine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(tert-butyldimethylsilyl)]-5-(N-methyl-N-trifluoroacetamido)methyluridine (protected form); 5-N-Methyl-N-trifluoroacetylaminomethyl Uridine; Trifluoroacetamidomethyl Uridine Derivative; Modified Uridine Phosphoramidite Intermediate
EINECS	Contact for details

Quality Control

Our 5-(n-Methyl-n-Trifluoromethylacetyl)Aminomethyl Uridine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and production applications. Each lot undergoes comprehensive analytical characterization using HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting full compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. Use in a dry, well-ventilated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.