Description

5'-Dmtr-2-Thio-Uridine is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis and medicinal chemistry research. Its core value lies in enabling the precise construction of modified RNA sequences, which are critical for developing advanced therapeutics and diagnostic tools. This compound is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense technology, siRNA development, and nucleic acid chemistry.

Application

• Oligonucleotide Synthesis: A key phosphoramidite building block for the solid-phase synthesis of thio-modified RNA oligonucleotides.
• Antisense & siRNA Therapeutics: Used to incorporate sulfur modifications into RNA strands to enhance nuclease resistance and improve pharmacokinetic properties of therapeutic oligonucleotides.
• Medicinal Chemistry Research: Serves as a crucial intermediate in the development of novel nucleoside analogs with potential antiviral or anticancer activity.
• Biochemical Probes: Enables the creation of labeled or modified RNA probes for studying RNA-protein interactions, structure, and function.
• Process Development: Used in scaling up the production of modified oligonucleotides for clinical and commercial applications.

Basic Information

Product Name	5'-Dmtr-2-Thio-Uridine
CAS No.	163496-06-8
Molecular Formula	C31H32N2O7S
Molecular Weight	576.66 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2-thiouridine; 2-Thio-5'-O-DMT-uridine; 1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-2-yl]-2-sulfanylpyrimidin-4-one; 2-Thiouridine, 5'-O-(4,4'-dimethoxytrityl)-; DMT-2-ThioU; 5'-DMT-2-thioU
EINECS	Contact for details

Quality Control

Our 5'-Dmtr-2-Thio-Uridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.