Description

Toremifene n-Oxide CAS NO 163130-29-8 is a key pharmaceutical intermediate and metabolite of the selective estrogen receptor modulator (SERM) toremifene. This compound is of significant importance for research and development in the field of oncology and endocrinology. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions for analytical reference standards, metabolite studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quality control and analytical method validation of toremifene and its related products.
• Metabolite Research: Critical for pharmacokinetic and pharmacodynamic studies to understand the metabolism, efficacy, and safety profile of toremifene.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and scale-up production of high-purity toremifene citrate.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate SERM mechanisms, hormone-dependent cancers (like breast cancer), and other endocrine disorders.
• Impurity Profiling: Essential for identifying and quantifying oxidative degradation impurities in toremifene drug substance and finished dosage forms to ensure product stability and compliance.

Basic Information

Product Name	Toremifene n-Oxide
CAS No.	163130-29-8
Molecular Formula	C₂₆H₂₈ClNO₂
Molecular Weight	421.96 g/mol
Synonyms	Toremifene N-Oxide; Toremifene Oxide; (Z)-4-Chloro-1,2-diphenyl-1-{4-[2-(N,N-dimethylamino)ethoxy]phenyl}-1-butene N-Oxide; FC-1157a N-Oxide; 2-{4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine N-Oxide
EINECS	Contact for details

Quality Control

Our Toremifene n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for identification, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Assay (HPLC)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.