Description

5-Bromo-4-Methoxythiophene-3-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its acid chloride functionality and bromo-methoxy substituted thiophene core. This compound is essential for the efficient synthesis of complex molecules, enabling the rapid introduction of the 5-bromo-4-methoxythiophene-3-carbonyl moiety into target structures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging the thiophene scaffold for bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers and organic electronic materials, where the thiophene unit is valued for its conductive properties.
• Chemical Biology Probes: Employed in the creation of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	5-Bromo-4-Methoxythiophene-3-Carbonyl Chloride
CAS No.	162848-22-8
Molecular Formula	C7H4BrClO2S
Molecular Weight	267.53 g/mol
Synonyms	5-Bromo-4-methoxy-3-thiophenecarbonyl chloride; 3-Thiophenecarbonyl chloride, 5-bromo-4-methoxy-; 5-Bromo-4-methoxythiophene-3-carboxylic acid chloride; 162848-22-8; 5-Bromo-4-methoxy-thiophene-3-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-4-Methoxythiophene-3-Carbonyl Chloride adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with strong acids and organic solvents; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Isolate from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.