Description

3-(2-Deoxy-5-o-Phosphono-β-D-Erythro-Pentofuranosyl)-3,4-Dihydro-5H-Imidazo[2,1-I]Purine-5-Thione is a high-purity, nucleoside analogue derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel therapeutic agents, particularly in antiviral and anticancer drug discovery programs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of next-generation nucleotide-based therapies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel antiviral and anticancer nucleotide analogues.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related biological pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.
• Academic Research: Utilized in universities and research institutes for studying nucleic acid chemistry and designing novel bioactive molecules.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Item	Detail
Product Name	3-(2-Deoxy-5-o-Phosphono-β-D-Erythro-Pentofuranosyl)-3,4-Dihydro-5H-Imidazo[2,1-I]Purine-5-Thione
CAS No.	162791-64-2
Molecular Formula	C12H15N5O6PS
Molecular Weight	388.32 g/mol
Synonyms	2'-Deoxy-5'-O-phosphono-3,4-dihydro-5H-imidazo[2,1-i]purine-5-thione; 2'-Deoxyadenosine-5'-monophosphate thio analogue; 5-Thio-dAMP analogue; Imidazopurine thione nucleoside phosphate; 5H-Imidazo[2,1-i]purine-5-thione, 3-(2-deoxy-5-O-phosphono-β-D-erythro-pentofuranosyl)-3,4-dihydro-; Nucleoside phosphonate intermediate; Antiviral nucleoside intermediate
EINECS	Contact for details

Quality Control

Our 3-(2-Deoxy-5-o-Phosphono-β-D-Erythro-Pentofuranosyl)-3,4-Dihydro-5H-Imidazo[2,1-I]Purine-5-Thione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical research. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment. We support development from research to commercial scale with consistent quality and reliable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.