Description

Temsirolimus Acetonide CAS NO 162635-03-2 is a potent semi-synthetic derivative of rapamycin (sirolimus) specifically designed for enhanced stability and targeted therapeutic action. This compound is a critical pharmaceutical intermediate in the synthesis of the active metabolite of temsirolimus, a key mTOR inhibitor used in oncology. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of targeted cancer therapies, particularly for renal cell carcinoma and other solid tumors.

Application

• Pharmaceutical Intermediate: Primary use in the commercial synthesis of the active pharmaceutical ingredient (API) Temsirolimus.
• Oncology Drug Development: Serves as a key precursor in R&D for novel mTOR (mammalian target of rapamycin) inhibitor formulations.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Biochemical Research: Employed in cell signaling pathway studies to investigate the role of mTOR in cell growth, proliferation, and angiogenesis.
• Pre-clinical Studies: Utilized in the formulation of drug candidates for pharmacokinetic and pharmacodynamic evaluations in animal models.

Basic Information

Product Name	Temsirolimus Acetonide
CAS No.	162635-03-2
Molecular Formula	C56H87NO16
Molecular Weight	1022.29 g/mol
Synonyms	CCI-779 Acetonide; Temsirolimus 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate] Acetonide; Rapamycin 42-Ester with 3-Hydroxy-2-(hydroxymethyl)-2-methylpropionic Acid, Cyclic 2,3-Carbonate with (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone; Torisel Intermediate
EINECS	Contact for details

Quality Control

Our Temsirolimus Acetonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.