Description

Salirasib CAS NO 162520-00-5 is a potent and selective farnesyltransferase inhibitor that disrupts the Ras signaling pathway, a key target in oncology research. This small molecule compound is critical for investigating novel therapeutic strategies against various cancers, particularly those driven by mutated Ras proteins. It is an essential research-grade chemical for pharmaceutical R&D, academic institutions, and biotechnology companies focused on oncology, signal transduction, and drug discovery.

Application

• Oncology Research: Primary tool for studying the inhibition of Ras protein farnesylation and its role in cancer cell proliferation and survival.
• Signal Transduction Studies: Used to elucidate the Ras/MAPK pathway and its downstream effects in cellular models.
• Preclinical Drug Development: Serves as a reference compound or lead molecule in the development of novel anti-cancer therapeutics.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro enzymatic assays to evaluate farnesyltransferase activity.
• Academic Research: Fundamental reagent for molecular biology and pharmacology studies investigating oncogenic signaling networks.
• Mechanism of Action (MoA) Studies: Critical for validating the therapeutic potential of targeting protein prenylation in disease models.

Basic Information

Product Name	Salirasib
CAS No.	162520-00-5
Molecular Formula	C27H30N2O4S
Molecular Weight	478.61 g/mol
Synonyms	Farnesylthiosalicylic Acid; FTS; (2-[(2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)benzoic Acid; S-trans,trans-Farnesylthiosalicylic Acid; 2-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic Acid; Salirasib Fumarate (salt form); Ras Inhibitor FTS; NSC 710305
EINECS	Contact for details

Quality Control

Our Salirasib is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. Keep the container sealed to protect the hygroscopic and light-sensitive material from moisture and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.