Description

tert-Butyl 3-(Azidomethyl)Piperidine-1-Carboxylate (Saltdata: Free) is a high-purity, protected piperidine derivative featuring an azidomethyl functional group, serving as a critical synthetic intermediate. This compound is essential for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetic Synthesis: Used to incorporate constrained piperidine scaffolds into peptide analogs to enhance metabolic stability and bioavailability.
• Click Chemistry: The azide group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer chemistry applications.
• Ligand and Probe Development: Serves as a precursor for creating chemical probes and ligands for biological target identification and validation.
• Agrochemical Research: Employed in the discovery and development of new crop protection agents and pesticides.
• Material Science: Can be used to functionalize polymers and surfaces via its reactive azide handle.

Basic Information

Product Name	tert-Butyl 3-(Azidomethyl)Piperidine-1-Carboxylate (Saltdata: Free)
CAS No.	162167-94-4
Molecular Formula	C12H22N4O2
Molecular Weight	254.33 g/mol
Synonyms	1-Boc-3-(azidomethyl)piperidine; 1-(tert-Butoxycarbonyl)-3-(azidomethyl)piperidine; 3-(Azidomethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 3-(azidomethyl)piperidine-1-carboxylate; 3-Azidomethyl-piperidine-1-carboxylic acid tert-butyl ester; N-Boc-3-(azidomethyl)piperidine; Boc-3-(azidomethyl)piperidine; 162167-94-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Azidomethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.