Description

2-(Trifluoromethoxy)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value proposition lies in the introduction of the trifluoromethoxy group, a moiety prized for its ability to dramatically enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with improved properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the trifluoromethoxy-phenyl moiety into drug candidates to optimize their pharmacokinetic profiles.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group contributes to enhanced biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystal compounds used in display technologies.
• Polymer Chemistry: Employed as a monomer or modifying agent to incorporate aromatic and fluorinated segments into high-performance polymers.
• Organic Synthesis Reagent: A fundamental reagent for Friedel-Crafts acylation and other reactions to form ketones, amides, and esters under mild conditions.
• Material Science Research: Used in the development of novel organic electronic materials and coatings with specific electronic or surface properties.

Basic Information

Product Name	2-(Trifluoromethoxy)Benzoyl Chloride
CAS No.	162046-61-9
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	2-(Trifluoromethoxy)benzoyl chloride; o-(Trifluoromethoxy)benzoyl chloride; 2-(Trifluoromethoxy)benzoic acid chloride; Benzoyl chloride, 2-(trifluoromethoxy)-; α,α,α-Trifluoro-o-anisoyl chloride; 2-Trifluoromethoxybenzoyl chloride
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Benzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.