Description

Cyclohexanecarboxylic Acid, 4-(Chlorocarbonyl)-, Methyl Ester, cis- (9Ci) is a high-purity, functionalized cyclohexane derivative designed for advanced chemical synthesis. This compound serves as a critical chiral building block and acylating agent, enabling the precise introduction of the cis-4-(chlorocarbonyl)cyclohexanecarboxylate moiety into target molecules. It is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require reliable, high-quality intermediates for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where its stereochemistry influences biological activity.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialized polyesters and polyamides with tailored thermal and mechanical properties.
• Liquid Crystal & OLED Materials: Serves as a precursor for mesogens and electron-transport materials in display and lighting technologies.
• Peptide Mimetics & PROTACs: Utilized to incorporate rigid, cyclohexyl-based linkers and functional handles in the design of bioactive peptides and proteolysis-targeting chimeras.
• Chemical Research & Development: A versatile reagent for exploring new reaction pathways and synthesizing novel chemical entities in academic and industrial R&D labs.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 4-(Chlorocarbonyl)-, Methyl Ester, cis- (9Ci)
CAS No.	161975-35-5
Molecular Formula	C9H13ClO3
Molecular Weight	204.65 g/mol
Synonyms	cis-Methyl 4-(chlorocarbonyl)cyclohexanecarboxylate; Methyl cis-4-(chloroformyl)cyclohexanecarboxylate; cis-4-(Methoxycarbonyl)cyclohexanecarbonyl chloride; (1r,4r)-4-(Methoxycarbonyl)cyclohexanecarbonyl chloride; (1s,4s)-4-(Methoxycarbonyl)cyclohexanecarbonyl chloride; 4-(Chlorocarbonyl)cyclohexanecarboxylic acid methyl ester, cis-; Cyclohexanecarboxylic acid, 4-(chlorocarbonyl)-, methyl ester, (1r,4r)-rel-
EINECS	Contact for details

Quality Control

Every batch of Cyclohexanecarboxylic Acid, 4-(Chlorocarbonyl)-, Methyl Ester, cis- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency meet your specific R&D or cGMP starting material requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.