Description

n-(S-Acetylmercaptoacetyl)-4-Isothiocyanate-Phenylalanyl-Glycyl-Glycine Ethyl Ester is a specialized, high-purity synthetic peptide derivative designed for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and conjugation reagent, enabling the precise modification and labeling of biomolecules for targeted applications. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and targeted drug delivery systems, where its unique reactive groups facilitate the creation of stable, site-specific linkages.

Application

• Bioconjugation Reagent: For the site-specific labeling of proteins, antibodies, and other biomolecules with fluorescent dyes, drugs, or affinity tags.
• Proteomics Research: Used in the synthesis of activity-based probes (ABPs) to study enzyme function and identify novel drug targets.
• Antibody-Drug Conjugate (ADC) Development: Acts as a key linker-payload intermediate in the construction of next-generation targeted cancer therapeutics.
• Diagnostic Assay Development: Employed in the creation of sensitive and specific diagnostic reagents and immunoassays.
• Peptide Synthesis: Serves as a protected, activated intermediate in solid-phase and solution-phase peptide synthesis.
• Chemical Biology Tool: For studying protein-protein interactions and cellular pathways through covalent modification.

Basic Information

Product Name	n-(S-Acetylmercaptoacetyl)-4-Isothiocyanate-Phenylalanyl-Glycyl-Glycine Ethyl Ester
CAS No.	161876-61-5
Molecular Formula	C23H28N4O7S2
Molecular Weight	536.62 g/mol
Synonyms	4-Isothiocyanatophenylalanyl-glycyl-glycine S-acetylmercaptoacetyl ethyl ester; S-Acetylmercaptoacetyl-Phe(p-NCS)-Gly-Gly-OEt; N-[2-[(Acetylthio)acetyl]-L-tyrosyl]glycylglycine ethyl ester 4-isothiocyanate; Acm-Phe(p-NCS)-Gly-Gly-OEt; (S)-2-((2-((2-((S)-2-Acetamido-3-(4-isothiocyanatophenyl)propanamido)acetamido)acetamido)-3-phenylpropanoyl)thio)acetic acid ethyl ester; Linker for ADC; Peptide-based isothiocyanate reagent.
EINECS	Contact for details

Quality Control

Our n-(S-Acetylmercaptoacetyl)-4-Isothiocyanate-Phenylalanyl-Glycyl-Glycine Ethyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for production where applicable, and our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical and biotech partners.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solvent Residue (GC)	Meets ICH limits
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.