Description

Esomeprazole Potassium CAS NO 161796-84-5 is the potassium salt form of esomeprazole, the (S)-isomer of omeprazole, and a potent proton pump inhibitor (PPI). This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacture of advanced anti-ulcerative and gastroesophageal reflux disease (GERD) medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the formulation of next-generation, enantiomerically pure therapeutic products.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for acid-related disorders.
• GERD Treatment Formulations: Used in delayed-release tablets, capsules, and intravenous solutions for treating gastroesophageal reflux disease.
• Peptic Ulcer Therapy: A key component in drugs designed to heal gastric and duodenal ulcers, including those induced by NSAIDs.
• Zollinger-Ellison Syndrome Management: Incorporated into formulations for the long-term control of pathological hypersecretory conditions.
• Helicobacter pylori Eradication: Used in combination therapy regimens (e.g., with antibiotics) for H. pylori infection treatment.
• Pharmaceutical R&D: Serves as a reference standard and starting material for developing new dosage forms and drug delivery systems.
• Generic Drug Manufacturing: Essential for producing bioequivalent generic versions of branded esomeprazole medications.

Basic Information

Product Name	Esomeprazole Potassium
CAS No.	161796-84-5
Molecular Formula	C17H18KN3O3S
Molecular Weight	383.51 g/mol
Synonyms	(S)-Omeprazole Potassium Salt; Esomeprazole K Salt; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole Potassium Salt; Nexium® Potassium Salt; Perprazole Potassium; Esoz-K; (S)-Omeprazole Potassium
EINECS	Contact for details

Quality Control

Our Esomeprazole Potassium is manufactured under strict quality management systems, targeting standards suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure identity, potency, and purity. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment. We support compliance with ICH Q7, GMP, and relevant pharmacopoeial guidelines (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.