Description

1H-Indole-5-Carbonyl Chloride (9Ci) is a versatile and highly reactive organic building block, specifically an acid chloride derivative of indole-5-carboxylic acid. Its primary value lies in its role as a key intermediate for the synthesis of complex molecules, enabling efficient amide bond formation and other nucleophilic acyl substitution reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and plant growth regulators with indole-based structures.
• Peptide Mimetics & Bioconjugation: Facilitates the introduction of the indole moiety into peptides and proteins for creating mimetics or diagnostic probes.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probes: Employed to synthesize activity-based probes for studying enzyme function and biological pathways.
• Academic & Contract Research: A valuable reagent for method development and exploratory organic synthesis in R&D laboratories.

Basic Information

Product Name	1H-Indole-5-Carbonyl Chloride (9Ci)
CAS No.	161397-68-8
Molecular Formula	C9H6ClNO
Molecular Weight	179.60 g/mol
Synonyms	Indole-5-carbonyl chloride; 5-Indolecarbonyl chloride; 1H-Indole-5-carboxylic acid chloride; 5-Carboxyindole acid chloride; 5-Indolylcarbonyl chloride; 1H-Indol-5-ylcarbonyl chloride; 5-(Chlorocarbonyl)-1H-indole
EINECS	Contact for details

Quality Control

Our 1H-Indole-5-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.