Description

Adenosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt is a chemically modified, non-hydrolyzable analog of cyclic adenosine monophosphate (cAMP). This compound serves as a potent and selective inhibitor of cAMP-dependent protein kinase (PKA), making it an indispensable tool for elucidating intracellular signaling pathways. It is primarily utilized by researchers and developers in pharmaceutical discovery, biochemical research, and cell biology to study the role of PKA in various physiological and pathological processes.

Application

• Biochemical Research: As a key reagent for studying cAMP/PKA signaling cascades in vitro and in cell-based assays.
• Pharmaceutical Development: Used in target validation and screening for drugs intended to modulate PKA activity.
• Cell Signaling Studies: Investigating the role of PKA in cellular functions such as metabolism, gene expression, and cell proliferation.
• Neuroscience Research: Exploring PKA's involvement in neuronal plasticity, memory formation, and neurotransmitter release.
• Cardiovascular Research: Studying the regulation of cardiac contractility and ion channel function by PKA.
• Enzyme Kinetics: Serving as a competitive inhibitor in enzymatic studies to determine kinetic parameters of PKA.

Basic Information

Product Name	Adenosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt
CAS No.	161308-33-4
Molecular Formula	C10H12N5O5PS · xC6H15N
Molecular Weight	Free acid: 345.26 g/mol (Contact for salt form details)
Synonyms	Rp-cAMPS triethylammonium salt; Rp-Adenosine 3',5'-cyclic monophosphorothioate; Rp-cAMPS; cAMP-S, Rp-isomer; Adenosine cyclic 3',5'-(hydrogen phosphorothioate) Rp-isomer; PKA Inhibitor, Rp-cAMPS; (Rp)-Adenosine-3',5'-cyclic monophosphorothioate
EINECS	Contact for details

Quality Control

Our Adenosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer is produced under stringent conditions to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile is supplied with every shipment to meet the rigorous standards of academic and industrial research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.