Description

1,3-Cyclohexanedicarbonyl Difluoride, cis- (9Ci) CAS NO 161117-17-5 is a high-purity, reactive fluorinated building block characterized by its cis-cyclohexane backbone. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, enabling the efficient introduction of difluoromethylene and carbonyl functionalities. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, including potential active ingredients and novel materials.

Application

The unique structure of cis-1,3-Cyclohexanedicarbonyl Difluoride makes it a critical reagent in specialized synthetic pathways. Key application areas include:

• Pharmaceutical Intermediate: Synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Research: Building block for novel herbicides, fungicides, and insecticides where fluorine substitution enhances bioavailability and stability.
• Material Science: Precursor for fluorinated polymers, coatings, and liquid crystals with tailored thermal and chemical resistance.
• Organic Synthesis: Key substrate in cross-coupling reactions, nucleophilic substitutions, and ring-opening polymerizations.
• Chemical Biology: Probe development for studying enzyme mechanisms and protein-ligand interactions.
• Fluorine Chemistry R&D: Fundamental research on new fluorination methodologies and the properties of fluorinated cyclohexane derivatives.

Basic Information

Product Name	1,3-Cyclohexanedicarbonyl Difluoride, cis- (9Ci)
CAS No.	161117-17-5
Molecular Formula	C8H10F2O2
Molecular Weight	176.16 g/mol
Synonyms	cis-1,3-Cyclohexanedicarboxylic Acid Difluoride; cis-Hexahydroisophthaloyl Difluoride; 1,3-Cyclohexanedicarboxylic Acid, 1,3-Difluoride, cis-; cis-Cyclohexane-1,3-dicarbonyl Difluoride; cis-1,3-Bis(fluorocarbonyl)cyclohexane; cis-Cyclohexane-1,3-dicarboxylic Acid Difluoride; 1,3-Cyclohexanedicarbonyl Difluoride (cis-); Hexahydro-1,3-isophthaloyl Difluoride (cis-)
EINECS	Contact for details

Quality Control

Our 1,3-Cyclohexanedicarbonyl Difluoride, cis- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and isomeric consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (cis-)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.