Description

3'-Deoxy-5'-o-Trityl-D-Uridine is a key nucleoside derivative and a vital protected intermediate in synthetic organic chemistry. Its primary value lies in enabling the controlled synthesis of modified oligonucleotides and nucleoside analogs, which are essential for pharmaceutical research and development. This high-purity building block is critical for researchers and manufacturers in the fields of antiviral drug discovery, antisense oligonucleotide (ASO) production, and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the solid-phase or solution-phase synthesis of modified DNA/RNA strands for research and therapeutic applications.
• Antisense Technology: Serves as a precursor for creating antisense oligonucleotides (ASOs) that target specific mRNA sequences.
• Medicinal Chemistry & R&D: Enables structure-activity relationship (SAR) studies by providing a protected scaffold for further chemical modification.
• Bioconjugation: Acts as a starting material for labeling nucleotides with probes or tags for diagnostic assays.
• Academic Research: Fundamental reagent for studying nucleic acid chemistry, enzyme mechanisms, and biochemical pathways.

Basic Information

Product Name	3'-Deoxy-5'-o-Trityl-D-Uridine
CAS No.	161110-05-0
Molecular Formula	C32H30N2O6
Molecular Weight	538.59 g/mol
Synonyms	5'-O-Trityl-3'-deoxyuridine; 3'-Deoxy-5'-O-trityluridine; D-Uridine, 3'-deoxy-5'-O-trityl-; 5'-O-(Triphenylmethyl)-3'-deoxyuridine; 3'-Deoxy-5'-O-(triphenylmethyl)uridine; Tritylated 3'-Deoxyuridine; 3'-dUrd(5'-OTr); Protected 3'-Deoxyuridine
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-5'-o-Trityl-D-Uridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality assurance protocols are designed to meet the stringent requirements of advanced synthetic and life science industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.