Description

3’,5’-Di-o-Acetyl-2-Fluoro-2’-o-Trifluoro-Methanesulfonyladenosine is a high-purity, chemically modified nucleoside derivative, serving as a critical advanced intermediate in pharmaceutical research and development. Its value lies in its unique functionalization, which enables precise chemical transformations for creating novel therapeutic agents. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on developing antiviral drugs, nucleotide-based prodrugs, and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used in the development of next-generation antiviral compounds targeting viruses such as hepatitis, influenza, and coronaviruses.
• Oncology Research: Serves as a precursor in the creation of nucleotide-based chemotherapeutic agents and targeted cancer therapies.
• Biochemical Probe Development: Utilized to create labeled or modified nucleotides for studying enzyme mechanisms and cellular processes.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by providing a versatile scaffold for further chemical modification.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale production of nucleotide-based pharmaceuticals.

Basic Information

Product Name	3’,5’-Di-o-Acetyl-2-Fluoro-2’-o-Trifluoro-Methanesulfonyladenosine
CAS No.	161109-76-8
Molecular Formula	C₁₇H₁₇F₄N₅O₉S
Molecular Weight	551.41 g/mol
Synonyms	2'-O-Trifluoromethanesulfonyl-2-fluoro-3',5'-di-O-acetyladenosine; 2-Fluoro-2'-O-triflyl-3',5'-di-O-acetyladenosine; 2'-O-(Trifluoromethylsulfonyl)-2-fluoro-3',5'-di-O-acetyladenosine; 2-Fluoro-3',5'-di-O-acetyl-2'-O-trifluoromethanesulfonyladenosine; Adenosine, 2-fluoro-3',5'-diacetate 2'-(trifluoromethanesulfonate); 161109-76-8; 2-F-3',5'-diAc-2'-OTf-Ado
EINECS	Contact for details

Quality Control

Every batch of 3’,5’-Di-o-Acetyl-2-Fluoro-2’-o-Trifluoro-Methanesulfonyladenosine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are developed to meet the exacting standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles by HPLC, NMR, and MS is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.