Description

Auristatin E is a highly potent synthetic derivative of dolastatin 10, a natural cytostatic peptide originally isolated from marine sources. Its primary value lies in its role as a cytotoxic warhead in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. This compound is essential for pharmaceutical R&D teams and manufacturers specializing in oncology therapeutics, particularly in the precision medicine and bioconjugation sectors. The product, Auristatin E CAS NO 160800-57-7, represents a critical building block for next-generation biopharmaceuticals.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic component linked to monoclonal antibodies for targeted delivery to cancer cells.
• Oncology Research: Used in preclinical and clinical research to study mechanisms of action and efficacy of novel ADC constructs.
• Biopharmaceutical Manufacturing: A key intermediate in the GMP production of approved and investigational ADC therapies.
• Drug Discovery: Employed in screening and developing new linker-payload technologies to improve therapeutic index.
• Chemical Biology: Utilized as a tool compound to investigate tubulin dynamics and mitosis inhibition.

Basic Information

Product Name	Auristatin E
CAS No.	160800-57-7
Molecular Formula	C₃₉H₆₇N₅O₇
Molecular Weight	718.0 g/mol
Synonyms	Dolastatin 10 derivative; (3S,4S,5S,6R,8R,9S,10E,12S,14S,15S,17S,18S,19S)-19-Amino-15-[(2S)-2-aminopropanoyl]oxy]-3-[(1R)-1-carboxyethyl]-12-ethyl-8,18-dihydroxy-4,6,10,14-tetramethyl-17-[(2S)-1-[(2S,3S)-3-methoxy-2-methyl-3-oxopropyl]amino]-1-oxopropan-2-yl]amino]-5,9-dioxo-1-oxa-7,11,16-triazacycloheptadec-10-ene-6-carboxylic acid; MMAE precursor; Monomethyl auristatin E precursor
EINECS	Contact for details

Quality Control

Our Auristatin E is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical development. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability and potency. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Assay	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.