Description

2,3,4,5,6-Pentamethylbenzoyl Chloride is a highly substituted benzoyl chloride derivative, serving as a critical acylating agent and versatile synthetic intermediate in advanced organic chemistry. Its sterically hindered structure and reactive acid chloride group make it invaluable for introducing the pentamethylbenzoyl moiety, which can impart significant steric and electronic effects to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients, ligands, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sterically hindered active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic and central nervous system diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the pentamethylbenzoyl group enhances stability and bioactivity.
• Ligand and Catalyst Preparation: Crucial for synthesizing specialized ligands for transition metal catalysis, including those used in asymmetric synthesis and polymerization processes.
• Polymer and Material Science: Acts as a monomer or modifying agent to create polymers with tailored thermal and mechanical properties for high-performance materials.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation, esterification, and amidation reactions to construct complex molecular architectures in research and development.
• Dye and Pigment Manufacturing: Intermediate for producing specialized colorants and photoactive compounds with enhanced lightfastness and chemical resistance.

Basic Information

Product Name	2,3,4,5,6-Pentamethylbenzoyl Chloride
CAS No.	160723-85-3
Molecular Formula	C12H15ClO
Molecular Weight	210.70 g/mol
Synonyms	Pentamethylbenzoyl Chloride; 2,3,4,5,6-Pentamethylbenzoyl Chloride; Benzoyl chloride, 2,3,4,5,6-pentamethyl-; Pentamethylbenzoyl chloride; 160723-85-3; Pentamethylbenzoylchloride; 2,3,4,5,6-Pentamethyl-benzoyl chloride
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentamethylbenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.