Description

6-(Difluoromethoxy)-2-[(S)-[(3,4-Dimethoxy-2-Pyridinyl)Methyl]Sulfinyl]-1H-Benzimidazole Sodium Salt is a high-purity, non-racemic pharmaceutical intermediate of significant commercial importance. Its primary value lies in its role as a key chiral building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly proton pump inhibitors. This compound is essential for manufacturers in the pharmaceutical and fine chemical industries requiring precise stereochemistry and stringent quality control for regulatory submissions.

Application

• Pharmaceutical Intermediate: Critical chiral precursor in the synthesis of next-generation proton pump inhibitor (PPI) APIs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of specific gastroesophageal reflux disease (GERD) and ulcer treatment medications.
• Asymmetric Synthesis: Serves as a valuable synthon in chiral pool synthesis for medicinal chemistry research and development.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing of target drug molecules.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and drug development services.

Basic Information

Product Name	6-(Difluoromethoxy)-2-[(S)-[(3,4-Dimethoxy-2-Pyridinyl)Methyl]Sulfinyl]-1H-Benzimidazole Sodium Salt
CAS No.	160488-53-9
Molecular Formula	C₁₆H₁₄F₂N₃O₄S•Na
Molecular Weight	421.35 g/mol
Synonyms	(S)-Omeprazole Sodium Salt; Dexlansoprazole Related Compound; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole Sodium Salt (common misnomer); Sodium (S)-6-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazol-1-ide; Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt, (S)-; Dexlansoprazole Impurity; Chiral PPI Intermediate; Sodium (S)-Omeprazole.
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)-2-[(S)-[(3,4-Dimethoxy-2-Pyridinyl)Methyl]Sulfinyl]-1H-Benzimidazole Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) providing identity, purity, impurity profile, and residual solvent data is supplied with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.